Development of Metronidazole Sustained-release Pellets
Metronidazole is also known as fossyol and flagyl. In addition to being used for anti-trichomonas and anti-amebic protozoa, in recent years, it is widely used ianti-anaerobicn infections. Metronidazole fights against amebic protozoa by inhibiting the redox reaction of the amebic protozoa, and then causing the protozoan's nitrogen chain to rupture. During its antibacterial process, the nitro is reduced to a cytotoxin, which acts on the DNA metabolism of bacteria to promote bacterial death. The latest research shows that metronidazole has a sensitizing effect on radiotherapy, and it can also be used for hyperlipidemia. Now the oral dosage forms of metronidazole on the market are mostly ordinary dosage forms taken by 3 times a day; because its most common adverse reaction is gastrointestinal reaction, in order to reduce the patient's frequency of administration, increase patient compliance and reduce adverse reactions, in this experiment, metronidazole pellets were prepared by centrifugal granulation powder gradation method and coated with aqueous dispersion of acrylic resin to prepare Metronidazole Sustained-release Pellets.